| 摘要 |
Disclosed are novel compounds represented by the following structural formula: <?in-line-formulae description="In-line Formulae" end="lead"?>R-X-Y;<?in-line-formulae description="In-line Formulae" end="tail"?> and physiologically acceptable salts thereof. R is a tricyclic core of a cannabinoid or substituted cannabinoid. X is a covalent bond, -CH<SUB>2</SUB>- or -CHR<SUB>1</SUB>-, wherein R<SUB>1 </SUB>a C1 to C3 substituted or unsubstituted alkyl group. Y is a heterocyclic ring, a substituted heterocyclic ring, a carbocyclic ring, a substituted carbocyclic ring, a fused bicyclic ring system, a substituted fused bicyclic ring system, a bridged bicyclic ring system, a substituted bridged bicyclic ring system, a bridged tricyclic ring system or a substituted bridged tricyclic ring system. Also disclosed is a method of stimulating a CB1 and/or CB2 receptor in a subject. The method comprises administering to the subject a therapeutically effective amount of R-X-Y.
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