发明名称 |
Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo(3,4:6,7)cycloheptalÄ1,2-bÜfuran derivatives. |
摘要 |
The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I) in stereochemically pure form from either of two enantiomerically pure precursors. The tetracyclic ringsystem having trans-fused five and seven membered rings is formed in an acid-catalysed cyclization reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines. |
申请公布号 |
ZA200404394(B) |
申请公布日期 |
2005.09.05 |
申请号 |
ZA20040004394 |
申请日期 |
2004.06.03 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
YOLANDE LYDIA LANG;BART PETRUS ANNA MARIA JOZEF MEDAER;GEORGES JOSEPH CORNELIUS HOORNAERT;THIERY BROSSETTE;FRANS JOSEF CORNELIUS COMPERNOLLE;MICHEL JOSEPH MARICE ANDRE GUILLAUME;HUA MAO;TOMASZ KOZLECKI |
分类号 |
A61K31/34;A61K31/343;A61P25/06;A61P25/22;A61P25/24;A61P25/28;A61P25/30;C07D307/93 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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