发明名称 |
Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
摘要 |
Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 Å.
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申请公布号 |
US2005191728(A1) |
申请公布日期 |
2005.09.01 |
申请号 |
US20040894335 |
申请日期 |
2004.07.19 |
申请人 |
KJELDSEN THOMAS B.;LUDVIGSEN SVEND |
发明人 |
KJELDSEN THOMAS B.;LUDVIGSEN SVEND |
分类号 |
C07K14/62;C12N1/15;C12N1/21;C12N15/17;(IPC1-7):C12N1/18;C07H21/04;C12N15/74 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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