OXAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEROF

摘要

The invention relates to compounds of formula (I) where R1 = H or C1-C4 alkyl, R2 = C4-C10 alkyl, a C3-C12 non-aromatic carbocyclic group, a 1,2,3,4-tetrahydronaphthalenyl, a heterocyclic group, a C1-C3 alkylene group with a carbocyclic group, a phenylalkylene group, a NR9R10 group, or R1 and R2, together with the nitrogen atom to which they are bonded, are either a piperazin-1-yl or 1,4-diazepan-1-yl, or a piperidin-1-yl or pyrrolidin-1-yl, R3, R4, R5, R6, R7, R8 independently = H or halogen, a C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl or S(O)nAlk group in the form of a base or acid addition salts and in the hydrated or solvated state. The invention further relates to a method for preparation and therapeutic use thereof.