发明名称 |
TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES, AND METHODS OF USE THEREOF |
摘要 |
One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are als o described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally , the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
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申请公布号 |
CA2555959(A1) |
申请公布日期 |
2005.09.01 |
申请号 |
CA20052555959 |
申请日期 |
2005.02.14 |
申请人 |
MOLECULAR INSIGHT PHARMACEUTICALS, INC. |
发明人 |
BABICH, JOHN;KRONAUGE, JAMES F., JR.;MARESCA, KEVIN P. |
分类号 |
A61K51/00;A61K51/04;C07D213/38;C07D233/54;C07D233/56;C07D235/10;C07D235/14;C07D235/20;C07D277/28;C07F5/00;C07F13/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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