| 摘要 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R<SUP>6 </SUP>is hydrogen, comprising treating a compound of formula (I), wherein R<SUP>6 </SUP>is chosen from C<SUB>1</SUB>-C<SUB>10 </SUB>alkyl, C<SUB>2</SUB>-C<SUB>10 </SUB>alkenyl, C<SUB>2</SUB>-C<SUB>10 </SUB>alkynyl, -(CR<SUP>7</SUP>R<SUP>8</SUP>)<SUB>t</SUB>(C<SUB>6</SUB>-C<SUB>14 </SUB>aryl), and -(CR<SUP>7</SUP>R<SUP>8</SUP>)<SUB>t</SUB>(4-10 membered heterocyclic), and wherein said C<SUB>6</SUB>-C<SUB>14 </SUB>aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C<SUB>1</SUB>-C<SUB>10 </SUB>alkyl, -OR<SUP>7</SUP>, and -N(R<SUP>7</SUP>R<SUP>8</SUP>), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
|
