发明名称 TRIAZOLE DERIVATIVES WHICH INHIBIT VASOPRESSIN ANTAGONISTIC ACTIVITY
摘要 Compounds of formula (I), or pharmaceutically acceptable derivatives thereof , wherein: Het represents 2-pyridinyl or 2-pyrimidinyl;R1 representsH,C1-3 alk yl or a nitrogen-containing heterocyclic ring having5 or 6 ring atoms; R2 represents H, benzyl or C 1-3 alkyl; and R3 represents H, methyl, methoxy or chloro; are useful for treating anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including moti on sickness), intrauterine growth retardation, inflammation (including rheumato id arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.
申请公布号 CA2554090(A1) 申请公布日期 2005.09.01
申请号 CA20052554090 申请日期 2005.01.11
申请人 PFIZER LIMITED 发明人 BRYANS, JUSTIN STEPHEN;JOHNSON, PATRICK STEPHEN;RYCKMANS, THOMAS;STOBIE, ALAN
分类号 A61K31/5517;A61P25/00;C07D401/14 主分类号 A61K31/5517
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