发明名称 |
SUBSTITUTED SPIRO AZABICYCLICS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
摘要 |
<p>The present application describes modulators of CCR3 of formula (Ia) and (Ib): (I) or pharmaceutically acceptable salt forms thereof, wherein Z, R<1>, R<2>, R<3>, R<4>, R<5>, R<5'>, R<6>, a, b, c, d, and u are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using said modulators are disclosed.</p> |
申请公布号 |
WO2005080376(A1) |
申请公布日期 |
2005.09.01 |
申请号 |
WO2005US05185 |
申请日期 |
2005.02.18 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;BATT, DOUGLAS, G.;WACKER, DEAN, A.;DELUCCA, GEORGE, V. |
发明人 |
BATT, DOUGLAS, G.;WACKER, DEAN, A.;DELUCCA, GEORGE, V. |
分类号 |
A61K31/397;A61K31/41;C07D205/04;C07D401/12;C07D403/12;C07D417/12;(IPC1-7):C07D401/12 |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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