| 发明名称 |
Nematode-extracted serine protease inhibitors and anticoagulant proteins |
| 摘要 |
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
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| 申请公布号 |
US2005191724(A1) |
申请公布日期 |
2005.09.01 |
| 申请号 |
US20050092336 |
申请日期 |
2005.03.29 |
| 申请人 |
CORVAS INTERNATIONAL, INC., A DELAWARE CORPORATION |
发明人 |
VLASUK GEORGE P.;STANSSENS PATRICK E.H.;MESSENS JORIS H.L.;LAUWEREYS MARC J.;LAROCHE YVES R.;JESPERS LAURENT S.;GANSEMANS YANNICK G.J.;MOYLE MATTHEW;BERGUM PETER W. |
| 分类号 |
C12N15/09;A61K35/56;A61K38/00;A61P7/02;C07K14/81;C12N9/99;C12N15/12;C12N15/19;(IPC1-7):C07K14/435;C07H21/04;A61K38/17;C12P21/06 |
主分类号 |
C12N15/09 |
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