DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN NUCLEAR RECEPTOR NR5A1 (NR5A1)

摘要

The invention provides a human NR5A1 which is associated with the cardiovascular diseases, endocrinological diseases, hematological diseases, inflammation, respiratory diseases, metabolic diseases, neurological diseases, urological diseases, cancer and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, hematological diseases, inflammation, respiratory diseases, metabolic diseases, neurological diseases, urological diseases, cancer and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NR5A1 as well as pharmaceutical compositions comprising such compounds.