HIGHLY POTENT hsiRNA MIXTURES AND METHODS FOR GENE SILENCING
摘要
Compositions and methods for making the same and uses of the composition are provided where the composition has a plurality of dsRNA fragments with overlapping sequences, each fragment having a size in the range of 18-30 nt, such that the composition is formed by enzymatic digestion of one or more large dsRNAs and less than 2nM of the composition is capable of specifically silencing expression of a target gene by at least 65% in transfected COS cells.
申请公布号
WO2005079299(A2)
申请公布日期
2005.09.01
申请号
WO2005US04409
申请日期
2005.02.14
申请人
NEW ENGLAND BIOLABS, INC.;TZERTZINIS, GEORGE;PETIT, CELINE