发明名称 CXCR3 ANTAGONISTS
摘要 Compounds having the formula: wherein A<SUP>4 </SUP>is N and X is -C(O)- or -CH<SUB>2</SUB>-, are provided, which are useful as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.
申请公布号 ZA200304342(B) 申请公布日期 2005.08.31
申请号 ZA20030004342 申请日期 2003.06.03
申请人 AMGEN SF, LLC 发明人 Julio C MEDINA;Michael G JOHNSON;An-Rong LI;Jiwen LIU;Alan Xi HUANG;Liusheng ZHU;Andrew P MARCUS
分类号 A61K;A61K31/165;A61K31/4439;A61K31/4709;A61K31/517;A61K31/519;A61K31/5377;A61P;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/00;A61P19/02;A61P19/06;A61P25/00;A61P27/02;A61P27/16;A61P29/00;A61P31/04;A61P31/12;A61P35/00;A61P37/02;A61P37/08;A61P43/00;C07C233/73;C07D;C07D213/40;C07D235/10;C07D235/14;C07D239/91;C07D249/12;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D403/06;C07D403/12;C07D405/04;C07D413/14;C07D417/04;C07D417/12;C07D471/04;C07D487/04;C07F 主分类号 A61K
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