发明名称 |
SPISULOSINE COMPOUNDS HAVING ANTITUMOUR ACTIVITY |
摘要 |
<p>The present invention is directed to the isolation and bioactive characterization of compounds isolated from the clam Spisula polynyma. These compounds include three sphingoid-type bases, spisulosines 285, 299 and 313 (1-3), each of which shows unique cytotoxicity against L1210 murine lymphocytic leukemia cells. In addition, sphingosine (also referred to as 4-sphingenine or octadeca-4-shpingenine, 4) and two related compounds, nonadeca-4-sphingenine (a one carbon longer homolog, 5) and sphinga-4,10-diene (a dehydrosphingosine deravitive, 6) were also obtained, These compounds also contribute to the cytotoxicity of the Spisula polynyma extracts, but did not cause the morphology changes observed with compounds 1-3.</p> |
申请公布号 |
EP1069894(B1) |
申请公布日期 |
2005.08.31 |
申请号 |
EP19990915898 |
申请日期 |
1999.04.09 |
申请人 |
THE BOARD OF TRUSTEES FOR THE UNIVERSITY OF ILLINOIS |
发明人 |
RINEHART, KENNETH;FREGEAU, NANCY;WARWICK, ROBERT;GARCIA GRAVALOS;AVILA, JESUS;FAIRCLOTH, GLYNN, THOMAS |
分类号 |
A61K31/133;A61K35/56;A61P35/00;C07C213/00;C07C215/00;C07C217/00;(IPC1-7):A61K31/13 |
主分类号 |
A61K31/133 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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