发明名称 |
METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE |
摘要 |
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form. |
申请公布号 |
ZA200501641(B) |
申请公布日期 |
2005.08.31 |
申请号 |
ZA20050001641 |
申请日期 |
2005.02.24 |
申请人 |
ALZA CORPORATION |
发明人 |
NOYMI V. YAM;NIPUN DAVAR;JULIE LEE;IRAN REYES;ATUL D. AYER |
分类号 |
A61K;C07D471/04;A61K9/00;A61K9/24;A61K9/30;A61K9/62;A61K31/506;A61K31/519;A61P;A61P25/18;A61P25/22;A61P25/24 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|