METHOD OF CONSTRUCTING NONHUMAN MAMMAL HAVING RNAi PHENOTYPE

摘要

It is an object of the present invention to develop a novel method for producing mammals such as mice having an RNAi phenotype, thereby enabling the production of RNAi-expressed progenies by a new mechanism to transfer information to progenies, and to improve a method for introducing dsRNA to improve the efficiency of obtaining mammals such as mice having an RNAi phenotype. The present invention provides a method for producing a non-human mammal with suppressed function of a target gene, which comprises injecting the double-stranded RNA (dsRNA) of the garget gene into the nucleus of a cell.