发明名称 |
RAPID RELEASE ENCAPSULATED BIOACTIVE AGENTS FOR INDUCING OR POTENTIATING AN IMMUNE RESPONSE AND METHODS OF USING THEREOF |
摘要 |
<p>A composition for inducing or potentiating an immune response, preferably a CTL, T helper cell, or neutralizing antibody response in a subject, comprising an antigen and/or a non-antigen bioactive agent capable of inducing or potentiating such an immune response encapsulated in a polymeric composition, wherein the polymeric composition comprises a blend of (a) a polymer present in an amount sufficient to provide structural integrity to the polymeric composition, and (b) a rapidly biodegradable component, a rapidly dissolving component, a rapidly swelling component, or a component that causes osmotic rupture of the encapsulated polymeric composition is disclosed. Single polymer compositions for achieving such an immune response are also disclosed. Methods for inducing or potentiating a CTL, T helper cell or neutralizing antibody response using the above-identified compositions are disclosed.</p> |
申请公布号 |
EP1009386(B1) |
申请公布日期 |
2005.08.31 |
申请号 |
EP19980943467 |
申请日期 |
1998.08.28 |
申请人 |
CORIXA CORPORATION;BROOKWOOD PHARMACEUTICALS INC. |
发明人 |
STAAS, JAY, K.;TICE, THOMAS, R.;RAYCHAUDHURI, SYAMAL;SLEATH, PAUL, R. |
分类号 |
A61K9/00;A61K9/16;A61K39/39;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|