| 发明名称 |
Process for obtaining symmetrical N,N'-malonyl-bis-diamides |
| 摘要 |
The invention relates to a process for obtaining pharmacologically active compounds used in medical practice for treatment of cardiovascular diseases. The process for obtaining symmetrical N,N'-malonyl-bis-diamides includes condensation of the malonic ester with the esters of the aromatic amino acids, in the molar ratio of 1:2, in inert solvent at the temperature of 170...215C.
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| 申请公布号 |
MD20040009(A) |
申请公布日期 |
2005.08.31 |
| 申请号 |
MD20040000009 |
申请日期 |
2003.12.29 |
| 申请人 |
INSTITUTUL DE KIMIE AL AKADEMIEJ DE SHTIINTSE A REPUBLICHIJ MOLDOVA |
发明人 |
SHEPELI FELIX;MAKAEV FLYUR;SHEPELI DIANA |
| 分类号 |
A61K31/167;A61P9/12;C07B43/06;C07C231/02;C07C233/01;(IPC1-7):C07C231/02 |
主分类号 |
A61K31/167 |
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