| 发明名称 |
IONTOPHORETIC DELIVERY OF ROTIGOTINE FOR THE TREATMENT OF PARKINSON'S DISEASE |
| 摘要 |
<p>By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.</p> |
| 申请公布号 |
EP1567146(A1) |
申请公布日期 |
2005.08.31 |
| 申请号 |
EP20030785652 |
申请日期 |
2003.11.21 |
| 申请人 |
SCHWARZ PHARMA AG |
发明人 |
WOLFF, HANS-MICHAEL;BOUWSTRA, JOHANNA, AALTJE;LI, GAI, LING;NUGROHO, AKHMAD, KHARIS |
| 分类号 |
A61K31/381;A61K9/00;A61K47/00;A61P25/16;(IPC1-7):A61K31/381 |
主分类号 |
A61K31/381 |
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