发明名称 |
Methods of inhibiting GPR-9-6 function |
摘要 |
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CC chemokine receptor GPR-9-6 and blocks the binding of a ligand (e.g., TECK) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to GPR-9-6 and inhibit the binding of a ligand (e.g., TECK) and/or modulate a function of GPR-9-6. The invention further relates to a method of modulating a function of GPR-9-6, and to the use of the antibodies, antigen-binding fragments and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
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申请公布号 |
US6936248(B1) |
申请公布日期 |
2005.08.30 |
申请号 |
US20000522752 |
申请日期 |
2000.03.10 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
ANDREW DAVID P.;ZABEL BRAIN A.;PONATH PAUL D. |
分类号 |
G01N33/50;A61K39/395;A61K45/00;A61P3/10;A61P11/06;A61P19/02;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/06;C07K16/24;C07K16/28;C07K19/00;C12N5/10;C12N15/09;C12P21/08;C12Q1/02;G01N33/15;G01N33/566;G01N33/58;(IPC1-7):A61K39/40 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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