CRYSTALLINE FORMS OF [R-(R*,R*)]-2-(4-FLUOROPHENYL)-BETA, DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID HEMI CALCIUM SALT (ATORVASTATIN)

摘要

The invention relates to crystalline forms of [R-R*,R*)]-2-(4-fluorophenyl)-beta-delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) employed as pharmaceuticals, named Form I, Form II and Form IV, defined by their X-ray powder diffraction pattern and/or NMR tests, as well as to processes for preparing the same, to pharmaceutical compositions containing them and to their use as hypolipidemic and hypocholesterolemic agents.