发明名称 |
Nucleic acids and proteins of a rat ganglioside GM1-specific alpha1-2fucosyltransferase and uses thereof |
摘要 |
A rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase is disclosed. Nucleotide sequences of a rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase, amino acid sequences of its encoded protein (including peptide or polypeptide), and derivatives thereof are described. Also described are fragments (and derivatives and analogs thereof) which comprise a domain of rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase with catalytic activity. Methods of production of rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase and derivatives and analogs thereof (e.g. by recombinant means) are provided. Methods of inhibiting the function of rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase (e.g. by means of antisense RNA) are provided. Methods of commercial scale use of the rat ganglioside GM<SUB>1</SUB>-specific alpha1->2fucosyltransferase in the production of fucosyl-saccharide compositions are described. Applications of these compositions, e.g. as additives for human nutritive compositions or immunotherapeutics for cancer, are disclosed.
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申请公布号 |
US6936448(B2) |
申请公布日期 |
2005.08.30 |
申请号 |
US20010040863 |
申请日期 |
2001.11.01 |
申请人 |
NORTHWEST BIOTHERAPEUTICS, INC. |
发明人 |
HOLMES ERIC H.;SHERWOOD ANNE L. |
分类号 |
A61K38/00;A61K39/00;C12N9/10;C12P19/18;C12P19/26;(IPC1-7):C12P21/06;C12N9/00;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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