SELECTIVE CRYSTALLIZATION OF 3-PYRIDYL-1-HYDROXYETHYLIDENE-1, 1-BISPHOSPHONIC ACID SODIUM AS THE HEMIPENTAHYDRATE OR MONOHYDRATE

摘要

THE PRESENT INVENTION DISCLOSES 3-PYRIDYL-L-HYDROXYETHYLIDENE-L, L-BISPHOSPHONIC ACID SODIUM HEMIPENTAHYDRATE AND MONOHYDRATE, METHODS OF PREPARING THE HEMIPENTAHYDRATE OR MONOHYDRATE THROUGH CONTROL OF THE NUCLEATION TEMPERATURE AND RATE OF CRYSTALLIZATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING ONE OR BOTH OF THE HYDRATE FORMS.