| 发明名称 |
Th1 inducing natural adjuvant for heterologous antigens |
| 摘要 |
The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of OprI-antigen fusion proteins to elicit the Type-1 response. More particularly, the present invention is directed to pharmaceutical formulations comprising OprI and/or OprI fusion proteins, optionally together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.
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| 申请公布号 |
US6936263(B2) |
申请公布日期 |
2005.08.30 |
| 申请号 |
US20020222100 |
申请日期 |
2002.08.16 |
| 申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW |
发明人 |
REVETS HILDE;CORNELIS PIERRE;DE BAETSELIER PATRICK |
| 分类号 |
A61K39/39;A61P37/04;C07K14/21;C07K14/44;C07K16/10;(IPC1-7):A61K39/00;A61K39/38;A61K39/385;A61K39/02;A61K39/108;A61K38/00;A61K9/127;C12N1/12;C12P1/00;C12P21/04 |
主分类号 |
A61K39/39 |
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