发明名称 |
Pharmaceutical compositions of adsorbates of amorphous drug |
摘要 |
A pharmaceutical composition comprising a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate is disclosed, wherein the pharmaceutical composition comprises a solid adsorbate comprising a low-solubility drug adsorbed onto a substrate to form an adsorbate, the substrate having a surface area of at least 20 m2/g, wherein at least a major portion of the drug in the adsorbate is amorphous; wherein the adsorbate provides improved concentration of the drug in a use environment relative to a slow-evaporation control composition comprising the drug and the substrate but formed by evaporation of solvent from a suspension of the drug in a solvent with the substrate suspended therein, the evaporation of the solvent for formation of the slow-evaporation control composition being conducted over a period of at least 30 minutes. Optionally, these compositions may also include a concentration-enhancing polymer.
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申请公布号 |
NZ529490(A) |
申请公布日期 |
2005.08.26 |
申请号 |
NZ20020529490 |
申请日期 |
2002.05.21 |
申请人 |
PFIZER PRODUCTS INC |
发明人 |
BABCOCK, WALTER CHRISTIAN;FRIESEN, DWAYNE THOMAS;SHANKER, RAVI MYSORE;SMITHEY, DANIEL TOD;TADDAY, RALPH |
分类号 |
A61K9/14;A61K9/16;A61K9/18;A61K31/404;A61K31/405;A61K31/428;A61K31/47;A61K31/496;A61K31/498;A61K31/519;A61K45/00;A61K47/02;A61K47/30;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P3/04;A61P3/06;A61P3/10;A61P7/02;A61P9/10;A61P9/12;A61P11/14;A61P25/08;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/02;A61P43/00;(IPC1-7):A61K9/18 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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