| 摘要 |
A peptide consists of the structure: Asp1Tyr2(SO3H)-Met3Gly4Trp5Met6Asp7Phe8amide wherein the structure is modified by N-terminal extension by pGlu-Gln at Asp1 or N-alkylation, N-acetylation, N-acylation or N-isopropylation of Asp1, and optionally one further substitution or modification at an amino acid other than Asp1 or one peptide bond. Also described are methods of N-terminally modifying CCK-8 peptides and pharmaceutical compositions comprising the peptide to treat obesity and/or type 2 diabetes, inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose excursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8
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