| 摘要 |
Disclosed are compounds of formula I, wherein: R1 and R3 are independently H or alkyl, R2 is H, alkyl or CH2CN, R4 is H, alkyl, alkenyl, alkynyl, CH2C(W)=CH2, (CH2)nAr, CH2CH=CHAr, CH2COPh, CH2CONHAr, C(U)NH(CH2)mAr, or (CH2)dY(CH2)eAr, U is O or S, W is halogen, X and Y are independently O, S or NR5, R5 is H, alkyl, alkenyl or together R3 and R5 form a ring, n and m are independently 0-4, d is 1-3, e is 0-1, Ar is optionally substituted phenyl, naphthyl or furan, The compounds are used in the manufacture of medicaments for use as positive modulators of nicotinic receptor agonists. (62) Divided out of 518450
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