Skin remodeling and regenerative compositions containing elastin peptide ligands having the amino acid sequence (XGXXPG)n

摘要

The present invention relates to skin care compositions providing a method of enhancing the remodeling of age damaged and sun damaged skin in mammals utilizing an elastin peptide (EP) ligand of the general formula (GXXPG)n and in particular the sequences of (VGVAPG)n and/or (GVAPGV)n, and/or (VAPGVG)n and/or (APGVGV)n and/or (PGVGVA)n and/or (GVGVAP)n and a galactosugar which modulates the effect of the elastin peptide ligand(EP) on its lectin the Elastin-Binding Receptor (EBR). wherin A is a peptide-forming residue of L-alanine; G is a peptide-forming residue of glycine P is a peptide-forming residue of L-proline V is a peptide-forming residue of L-valine X is a peptide-forming residue of a single unspecified amino acid Peptide representations in this application conform to the standard practice of writing the NH₂-terminal amino acid residue at the left of the formula and the CO₂ H-terminal amino acid residue at the right.