COMPLEXED POLYPEPTIDE AND ADJUVANT FOR IMPROVED VACCINES
摘要
Attachment of the strongly immunogenic polypeptide to a more weakly immunogenic polypeptide can precipitate and focus a CpG adjuvant to increase in vivo priming of a cytotoxic T-lymphocyte (CTL) response, and thus increase the immunogenicity of the more weakly immunogenic polypeptide. Accordingly, compositions that include a bipartite immunogenic polypeptide are provided herein. The bipartite polypeptide can include a CpG-interacting amino acid sequence fused to a CTL-activating amino acid sequence that can be heterologous to the CpG-interacting amino acid sequence. Also provided are methods of identifying and using a CpG-interacting amino acid sequence and a bipartite immunogenic polypeptide.
申请公布号
WO2005076975(A2)
申请公布日期
2005.08.25
申请号
WO2005US03754
申请日期
2005.02.04
申请人
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;WETTSTEIN, PETER, J.;STRAUSBAUCH, MIKE;HARDIN, HEATHER;BORSON, NANCY