METHOD AND COMPOSITION FOR THERAPY USING GENE ENCODING SECRETED PROTEIN SUCH AS INTERFERON-BETA

摘要

PROBLEM TO BE SOLVED: To eliminate problems (stabilization of a protein, reduction of adverse effect) accompanied with delivery of a secreted protein such as interferon protein as a therapeutic agent.

SOLUTION: A method and a pharmaceutical composition for modifying cells of a mammalian recipient with a DNA encoding a secreted protein such as human interferon in situ are provided. The method includes forming a secreted protein expression system in vivo or ex vivo and administering the expression system to the mammalian recipient. The expression system and the methods are useful for the localized and systemic delivery of interferons in situ.

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