发明名称 |
Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B |
摘要 |
The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a selective CYP26B inhibitor, the selective CYP26B inhibitor having at least 10-fold selectivity for CYP26B relative to CYP26A. In another embodiment, a method involves administering to the individual an effective amount of a selective CYP26A inhibitor, the selective CYP26A inhibitor having a chemical formula set forth in the specification. The invention further provides screening methods for identifying a selective CYP26A inhibitor or selective CYP26B inhibitor.
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申请公布号 |
US2005187298(A1) |
申请公布日期 |
2005.08.25 |
申请号 |
US20040010953 |
申请日期 |
2004.12.13 |
申请人 |
ALLERGAN, INC. |
发明人 |
VASUDEVAN JAYASREE;YANG RONG;WANG LIMING;LIU XIAOXIA;TSANG KWOK-YIN;LI LING;TAKEUCHI JANET;VU THONG;BEARD RICHARD;BHAT SMITA;CHANDRARATNA ROSHANTHA A. |
分类号 |
A61K31/19;A61K31/192;A61K31/35;A61K31/38;(IPC1-7):A61K31/192 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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