发明名称 |
Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
摘要 |
The present invention provides methods and constructs for selectively expressing an Apoptosis-Inducing Gene (AIG) in a population of cells that overexpress cyclooxygenase-2 (COX-2) to induce apoptosis in the cell. To achieve this goal a chimeric gene construct is used that comprises a cyclooxygenase-2 promoter (COX-2 promoter) that is operably linked to at least one AIG such that the COX-2 promoter is activated in cells that overexpress COX-2, thereby resulting in transcription and translation of the AIG, which in turn activates apoptosis in the cell. Thus, apoptosis is selectively induced in only those cells capable of overexpressing COX-2.
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申请公布号 |
US2005187177(A1) |
申请公布日期 |
2005.08.25 |
申请号 |
US20040023020 |
申请日期 |
2004.12.23 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
GODBEY W. T.;ATALA ANTHONY |
分类号 |
A61K48/00;C07K14/47;C07K14/525;C12N9/64;C12N15/867;C12P21/02;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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