METHODS AND COMPOSITIONS RELATED TO NEURONAL DIFFERENTIATION

摘要

Compositions and methods of the invention use a novel transactivator methodology for manipulation of the molecular mechanisms of cell determination for the production of a cell with a neuronal phentoype. A recombinant transcription factor or transactivator that binds the RE1 promoter element, REST-transactivator, was constructed by replacing the repressor domains of the transcriptional repressor REST with a transcriptional activation domain. The RE1 binding transactivator was designed to induce or manipulate the neuronal differentiation process.