METHOD FOR THE SEPARATION OF INTERMEDIATES WHICH MAY BE USEDFOR THE PREPARATION OF ESCITALOPRAM

摘要

The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3- hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4- dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitril e and an acylated derivative thereof with a compound which form a derivative o f the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3- hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.