THIOAMIDES AND SALTS THEREOF AND CYTOKINE PRODUCTION INHIBITORS CONTAINING BOTH

摘要

The invention provides cytokine production inhibitors useful as preventive o r therapeutic agents for diseases accompanied with abnormally enhanced immune function. Cytokine production inhibitors containing as the active ingredient thioamides represented by the general formula (I) or salts thereof: wherein A is N, NO, C-NO2, or C-CN; Hal is halogeno; M1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, a heterocycle, amino, O, S, SO, or SO2; M2 i s amino, O, S, or a single bond; R1 is halogeno, alkyl, or the like; R2 R3, R4 and R5 are each independently H, alkyl, or the like; R6 is halogeno, alkyl, or the like; Cy is cycloalkyl, cycloalkenyl, aryl, or a heterocycle; k, p and q are each independently an integer of 0 to 3; and r is an integer of 0 to 5.< /SDOAB>