发明名称 USE OF 2,5-DIHYDROXYBENZENESULPHONIC ACID IN THE PRODUCTION OF MEDICAMENTS FOR THE TREATMENT OF ANGIODEPENDENT DISEASES SUCH AS CANCER AND PSORIASIS
摘要 The invention relates to the use of 2,5-dihydroxybenzenesulphonic acid in th e production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforementioned compoun d and, in particular, the calcium and potassium salts thereof, for the treatme nt of two angiodependent diseases which present a reduction in apoptosis, namel y cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapoptotic capacities thereof, in th e treatment of chronic psoriatic plaques.
申请公布号 CA2555248(A1) 申请公布日期 2005.08.25
申请号 CA20052555248 申请日期 2005.02.16
申请人 ACTION MEDICINES, S.L. 发明人 CUEVAS SANCHEZ, PEDRO;LOZANO PUERTO, ROSA MARIA;ROMERO GARRIDO, ANTONIO;VALVERDE LOPEZ, SERAFIN;GIMENEZ GALLEDO, GUILLERMO
分类号 A61K31/185;A61K31/255;A61P17/06;A61P35/00 主分类号 A61K31/185
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