发明名称 |
MUCIN ANTIGEN VACCINE |
摘要 |
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and CD40 ligand. Also provided are methods of generating an immune response against cells expressing a mucin by administering an effective amount of the vector. Further provided are methods of generating an immune response against cancer cells expressing a mucin in an individual by administering an effective amount of the vector. Still further provided are methods of overcoming anergy to a mucin self antigen by administering an effective amount of the vector. |
申请公布号 |
WO2005051991(A3) |
申请公布日期 |
2005.08.25 |
申请号 |
WO2004US39812 |
申请日期 |
2004.11.23 |
申请人 |
SIDNEY KIMMEL CANCER CENTER;TANG, YUCHENG;DIESSEROTH, ALBERT |
发明人 |
TANG, YUCHENG;DIESSEROTH, ALBERT |
分类号 |
A61K39/00;C07K14/47;C07K14/705;C12N15/09;C12N15/62 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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