ANTIBODIES HAVING A MUTATED AMINO ACID RESIDUE AT POSITION 268 (CH2 REGION) IN CONSTANT REGIONS

摘要

Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcgR, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native polar or charged amino acid e.g. Gln, Asn, Glu, or Asp.