NOVEL HEPARIN-BINDING PEPTIDE DESIGNED FROM HEPARIN-BINDING SITE OF SNAKE VENOM-ORIGIN VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)-LIKE PROTEIN AND USE THEREOF

摘要

As a novel heparin-binding peptide which inhibits the binding of VEGF-A165 to heparin or heparan sulfate proteoglycan and by which various physiological reactions caused by interactions between KDR and VEGF-A165 can be regulated, it is intended to provide a heparin-binding peptide which is designed based on the heparin-binding site of a snake venom-origin VEGF-like protein vammin, contains at least a first partial amino acid sequence: R-P-R-X-K-Q-G (wherein X represents one of R, W, H and K) originating in the heparin-binding site as described above and consists of from 7 to 20 amino acid residues.