发明名称 |
THERAPEUTIC AND DIAGNOSTIC CONJUGATES FOR USE WITH MULTISPECIFIC ANTIBODIES |
摘要 |
Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds. |
申请公布号 |
WO2005077071(A2) |
申请公布日期 |
2005.08.25 |
申请号 |
WO2005US04177 |
申请日期 |
2005.02.11 |
申请人 |
IMMUNOMEDICS, INC.;MCBRIDE, WILLIAM J.;GOLDENBERG, DAVID, M.;NOREN, CARL;HANSEN, HANS, J. |
发明人 |
MCBRIDE, WILLIAM J.;GOLDENBERG, DAVID, M.;NOREN, CARL;HANSEN, HANS, J. |
分类号 |
A61K47/48;A61K51/04;A61K51/08;A61K51/10;C07K7/06;C07K16/18;C07K16/30;C07K16/44;C07K16/46 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|