AMORPHOUS SALTS OF ROSUVASTATIN

摘要

The invention provides the novel amorphous rosuvastatin magnesium and process for preparation thereof from crystalline rosuvastatin magnesium, rosuvastatin methyl ammonium salt and from rosuvastatin lactone. Rosuvastatin magnesium is, chemically, (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, magnesium salt (2:1) of Formula (I). Rosuvastatin magnesium is an antihypercholesterolemic drug used in the treatment of atherosclerosis.