METHOD OF IMMUNOMODULATION BY MEANS OF ADOPTIVE TRANSFER OF ANTIGEN-SPECIFIC CYTOTOXIC T-CELLS

摘要

A method for the production of antigen-specific cytotoxic T-cells (CTLs) by incubating a T cell-containing cell preparation with sai d antigen and isolating said antigen-specific CTLs, characterized by i) activa ting proliferation of CTLs in the cell preparation by in cubation with the antigen; ii) selectively transferring a vector into the proliferati ng CTLs, said vector containing a marker gene by means o f which marked and non-marked cells can be separated; and iii) separating the transf ected antigen-specific CTLs on the basis of said marker gene, is useful for immunomodulation.