发明名称 |
PROCESS FOR PRODUCING L-LYSINE BY FERMENTATION |
摘要 |
A bacterium belonging to the genus Escherichia, which is transformed by introducing, into its cells, a DNA coding for a dihydrodipicolinate synthase originating from a bacterium belonging to the genus Escherichia having mutation-to desensitize feedback inhibition by L-lysine and a DNA coding for an aspartokinase III originating from a bacterium belonging to the genus Escherichia having mutation to desensitize feedback inhibition by L-lysine; preferably a bacterium belonging to the genus Escherichia in which a dihydrodipicolinate reductase gene and a diaminopimelate dehydrogenase gene originating from Brevibacterium lactofermentum (or a succinyldiaminopimelate transaminase gene and a succinyldiaminopimelate deacylase gene) are further enhanced, is cultivated in an appropriate medium, L-lysine is produced and accumulated in a culture thereof, and L-lysine is collected from the culture. |
申请公布号 |
CA2178589(C) |
申请公布日期 |
2005.08.23 |
申请号 |
CA19942178589 |
申请日期 |
1994.11.28 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
KOJIMA, HIROYUKI;OGAWA, YURI;KAWAMURA, KAZUE;SANO, KONOSUKE |
分类号 |
C12N15/09;C12N1/21;C12N9/02;C12N9/06;C12N9/10;C12N9/12;C12N9/88;C12N15/00;C12N15/52;C12N15/54;C12N15/70;C12P13/06;C12P13/08;C12R1/185;C12R1/19 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|