发明名称 |
Relationship of ABC transport proteins with hematopoietic stem cells and methods of use thereof |
摘要 |
The present invention includes methods of performing ex vivo expansion of gene-modified hematopoietic stem cells which are useful for many applications involving bone marrow transplantation and ex vivo gene therapy. The present invention further includes the gene-modified hematopoietic stem cells that are used and produced by such methods. Such gene-modified hematopoietic stem cells can also contain a second heterologous gene. In addition, the present invention also includes methods of engrafting the gene-modified hematopoietic stem cells of the present invention into animals, including for ex vivo gene therapy and for reconstitution of hematopoietic cells in ablated mammals. The present invention also provides a method of isolating stem cells.
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申请公布号 |
US6933150(B1) |
申请公布日期 |
2005.08.23 |
申请号 |
US20000584586 |
申请日期 |
2000.05.31 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
SORRENTINO BRIAN;BUNTING KEVIN;SCHUETZ JOHN;NAKAUCHI HIROMITSU |
分类号 |
A61K35/12;A61K48/00;C07K14/705;G01N33/50;G01N33/569;G01N33/574;(IPC1-7):C12N5/00;C12N5/08;C12N15/63;C12N15/85;C12N15/87 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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