| 摘要 |
FIELD: medicine, immunology, hematology, pharmacy. ^ SUBSTANCE: invention relates to a method for assay of catalytic allo-antibodies to factor VIII able to cleave this factor VIII in mammal and determination of site indices in indicated molecule of factor VIII wherein cleaving with indicated catalytic allo-antibodies occurs. Also, invention relates to the development of inhibitor of factor VIII cleaving catalyzed by anti-bodies to factor VIII, and to a pharmaceutical composition comprising indicated catalytic allo-antibodies to factor VIII that are able to cleave factor VIII that are obtained in the process of realization of assay method said. Also, invention relates to pharmaceutical composition comprising indicated inhibitor of factor VIII cleaving catalyzed by indicated allo-antibodies to factor VIII. Also, invention relates to therapeutic applying indicated inhibitor of factor VIII cleaving catalyzed by indicated allo-antibodies that are able to cleave factor VIII and obtained in the process for realization of assay method said, and to pharmaceutical composition comprising indicated inhibitor of factor VIII cleaving catalyzed by indicated allo-antibodies to factor VIII. Invention provides expanding assortment of therapeutic agents used in pathology associated with disturbance in metabolism of blood factor VIII. ^ EFFECT: valuable properties of antibodies. ^ 47 cl, 1 tbl, 5 dwg, 6 ex |
