| 摘要 |
Polymeric molecules including glycopolymers useful for biomolecular recognition processes are provided comprising anchoring groups by which they can be immobilized onto surfaces. These molecules are easily synthesized. They are broadly described as molecules comprising a polymer backbone with pendent multivalent groups attached to the polymer backbone and an anchoring group attached to the polymer backbone for covalently or noncovalently attaching the molecule to a surface or another molecule. Such polymeric molecules can be attached to other molecules or surfaces to provide a wide range of bioactive materials. In addition, this invention provides sulfated glycopolymers which are useful for reducing blood coagulation, stimulating growth factors to bind to their receptors, stimulating cell proliferation and preventing degradation of soluble growth factors under conditions of low pH, heat, and proteolytic enzymes.
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