摘要 |
In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system. |
申请人 |
DIHEDRON CORPORATION;BALLATORE, CARLO;CASTELLINO, ANGELO, JOHN;DESHARNAIS, JOEL;GUO, ZIJAN;LI, QUING;NEWMAN, MICHAEL, JAMES;SUN, CHENGZAO |
发明人 |
BALLATORE, CARLO;CASTELLINO, ANGELO, JOHN;DESHARNAIS, JOEL;GUO, ZIJAN;LI, QUING;NEWMAN, MICHAEL, JAMES;SUN, CHENGZAO |