发明名称 |
BOTULINUM NEUROTOXIN B RECEPTORS AND USE THEREOF |
摘要 |
It is disclosed here that synaptotagmin I (syt I) and synaptotagmin II (syt II) are the cellular receptors for botulinum neurotoxin B (BoNT/B) that mediate the cellular entry and toxicity of BoNT/B. The BoNT/B binding domains of syt I and II are also disclosed. While syt I needs gangliosides for BoNT/B binding, syt II can bind to BoNT/B in the absence of gangliosides. Various nucleic acids and polypeptides that relate to the BoNT/B binding domain of syt I or II are disclosed. Further disclosed are methods of reducing BoNT/B toxicity, methods of identifying agents that can block the binding between BoNT/B and syt I or II, methods of identifying agents that can bind to the BoNT/B binding domain of syt I or II, and methods of detecting BoNT/B or Clostridium botulinum. |
申请公布号 |
WO2005016233(A3) |
申请公布日期 |
2005.08.18 |
申请号 |
WO2003US34348 |
申请日期 |
2003.10.28 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
CHAPMAN, EDWIN, RAYMOND;DONG, MIN |
分类号 |
C07H21/02;C07H21/04;C07K14/705 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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