发明名称 PEPTIDYLARGININE DEIMINASE 4 INHIBITOR
摘要 A compound represented by the following general formula (I) or a salt thereo f. [Chemical formula 1] (I) (In the formula, R1, R2, and R3 each independently represents hydrogen or C1-3 alkyl, provided that at least one of R1, R2, and R3 is not hydrogen; R4 represents substituted amino; and R5 represents optionally substituted carboxy.) Also provided is a peptidyl arginine deiminase type IV inhibitor. With this inhibitor, diseases in which a peptid yl arginine deiminase participates (e.g., articular rheumatism and multiple sclerosis) can be prevented and/or treated.
申请公布号 CA2555199(A1) 申请公布日期 2005.08.18
申请号 CA20052555199 申请日期 2005.02.03
申请人 YOKOHAMA CITY UNIVERSITY 发明人 HIDAKA, YUJI;SATO, MAMORU;HASHIMOTO, HIROSHI;SHIMIZU, TOSHIYUKI;YAMADA, MICHIYUKI
分类号 C07C279/14;A61K31/198;A61K38/00;A61K45/00;A61P19/02;A61P29/00;A61P43/00 主分类号 C07C279/14
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