A METHOD OF DETECTING ENZYME INHIBITOR RESISTANCE IN INDIVIDUALS

摘要

A method of detecting in an individual incomplete inhibition an enzyme involved in thrombus formation, especially platelet cyclooxygesane, is described. The method comprises the steps of obtaining from the individual a biological sample which contains the enzyme, adding an exogenous substrate for the enzyme to the sample to form a reaction mixture, and assaying the reaction mixture for any increase in a level of a metabolite of the enzyme. The method is especially suitable for detecting sub-optimal ASPIRIN inhibition in individuals undergoing ASPIRIN anti-thrombosis therapy. Kits for carrying out the method of the invention are also described.