PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY

摘要

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts thereof, wherein: Z<1>:1 is N or CH; ;Z<2> and Z<3> are each independently N or CR<7>; :R, R<2>, R<3>, R<4>, R<5>, R<6>, and R<7> are each independently H, R<8>, or R<9>; each R<8> is independently a hydrocarbyl group; and each R<9> is independently halo, NO2, alkoxy, CN, CF3, S03H, SO2NR<10>R<11>, S02R<12>, NR<13>R<14> (CH2)aCOOR<15>, (CH2)bCONR<16>R<17>, (CH2)C COR<18> or (CH2)dOH; a, b, c and d are each independently 0, 1 2 3 or 4; are each independently H or alkyl; provided that when R and R<2> are both H, Zis CH; or Z<2> is N; or Z is CH and Z<2> is N; and wherein the compound is other than 4-(4,5-dimethylthiazol-2-yl)-N-(3,4,5­trimethoxyphenyl)-2-pyrimidineamine or 4-(5-(2-hydroxyethyl)-4-methylthiazol-2-yl)­N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine. Further aspects relate to the use of compounds of formula (I) in the preparation of a medicament for treating one or more disorders selected from a proliferative disorder, a viral disorder, a CNS disorder, diabetes, stroke or alopecia.